their associated pathways.1
How cancer cells exploit these signaling pathways is still unknown and remains a core topic in cancer research and an important area of investigation for us.
Many intricate differences exist among tumor types and across patients, and some signaling pathways exhibit the ability to influence an immune response.2 With a focus on combination regimens, Genentech aims to advance a personalized approach, and a more comprehensive understanding of cancer and its complexities. Through scientific discovery, Genentech is dedicated to advancing the fight against cancer and identifying the next generation of targeted strategies.
ALK-mediated signal transduction can play an important role in NSCLC development and progression1-3Learn More
ROS1 signaling pathway has been linked to cancer development1,2Learn More
TRK pathway signal transduction can lead to tumor survival and growth1,2Learn More
VEGF pathway is a potent angiogenesis inducer1Learn More
MAPK is a key access controller in the MAPK signal transmission pathLearn More
Explore HER Pathway
Human epidermal growth factor receptor (HER) signaling has been linked to cancer.Learn More
The PI3K / AKT signal transduction pathway is the key regulator of normal cellular processes, including cell growth, proliferation, metabolism, motility, survival and apoptosis.Learn More
Personalized Cancer Vaccine (PCV)
An individualized approach to the activation of the anti-tumor immune responseLearn More
Combination based on PD-L1 checkpoint inhibitionLearn More