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Tumor Targets

Targeted strategies aim to recognize

altered or overexpressed proteins and

their associated pathways.1

How cancer cells exploit these signaling pathways is still unknown and remains a core topic in cancer research and an important area of investigation for us.

Many intricate differences exist among tumor types and across patients, and some signaling pathways exhibit the ability to influence an immune response.2 With a focus on combination regimens, Genentech aims to advance a personalized approach, and a more comprehensive understanding of cancer and its complexities. Through scientific discovery, Genentech is dedicated to advancing the fight against cancer and identifying the next generation of targeted strategies.

Explore ALK

ALK-mediated signal transduction can play an important role in NSCLC development and progression1-3

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Explore ROS1

ROS1 signaling pathway has been linked to cancer development1,2

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Explore TRK

TRK pathway signal transduction can lead to tumor survival and growth1,2

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Explore VEGF

VEGF pathway is a potent angiogenesis inducer1

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Explore MAPK

MAPK is a key access controller in the MAPK signal transmission path

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Explore HER Pathway

Human epidermal growth factor receptor (HER) signaling has been linked to cancer.

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Explore PI3K

The PI3K / AKT signal transduction pathway is the key regulator of normal cellular processes, including cell growth, proliferation, metabolism, motility, survival and apoptosis.

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Personalized Cancer Vaccine (PCV)

An individualized approach to the activation of the anti-tumor immune response

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Combination Strategy

Combination based on PD-L1 checkpoint inhibition

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  1. Luo J, Solimini NL, Elledge SE. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009;136:823-837. PMID: 19269363
  2. Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230