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Tumor Targets
Targeted strategies aim to recognize
altered or overexpressed proteins and
their associated pathways.1
How cancer cells exploit these signaling pathways is still unknown and remains a core topic in cancer research and an important area of investigation for us.
Many intricate differences exist among tumor types and across patients, and some signaling pathways exhibit the ability to influence an immune response.2 With a focus on combination regimens, Genentech aims to advance a personalized approach, and a more comprehensive understanding of cancer and its complexities. Through scientific discovery, Genentech is dedicated to advancing the fight against cancer and identifying the next generation of targeted strategies.
Explore ALK
ALK-mediated signal transduction can play an important role in NSCLC development and progression1-3
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Explore HER Pathway
Human epidermal growth factor receptor (HER) signaling has been linked to cancer.
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Explore PI3K
The PI3K / AKT signal transduction pathway is the key regulator of normal cellular processes, including cell growth, proliferation, metabolism, motility, survival and apoptosis.
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Personalized Cancer Vaccine (PCV)
An individualized approach to the activation of the anti-tumor immune response
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References
- Luo J, Solimini NL, Elledge SE. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009;136:823-837. PMID: 19269363
- Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230